表皮葡萄球菌中妥布霉素-卡那霉素-新霉素耐药质粒的特性分析
Characterization of the tobramycin-kanamycin-neomycin resistance plasmid in Staphylococcus epidermidis.
作者信息
Hecht D W, Parisi J T
出版信息
J Antibiot (Tokyo). 1980 Aug;33(8):891-4. doi: 10.7164/antibiotics.33.891.
A strain of Staphylococcus epidermidis was transduced to tobramycin resistance and all transductants were also resistant to kanamycin and neomycin. Results of curing studies also indicated that these resistances were controlled by a single determinant on a plasmid. Agarose gel electrophoresis of the plasmid DNA from parent, cured, and transduced strains showed a single plasmid was responsible and its molecular weight was calculated to be 2.85 x 10(6). Attempts to determine other properties of the organism controlled by this plasmid were unsuccessful.
一株表皮葡萄球菌被转导获得对妥布霉素的抗性，并且所有转导子也对卡那霉素和新霉素具有抗性。消除研究结果还表明，这些抗性由质粒上的单一决定簇控制。对亲本、消除后的菌株和转导菌株的质粒DNA进行琼脂糖凝胶电泳显示，单个质粒起作用，其分子量计算为2.85×10⁶ 。确定受该质粒控制的该生物体其他特性的尝试未成功。
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