Moffat A, Marks V, Gamble D R
J Clin Pathol. 1980 Sep;33(9):871-5. doi: 10.1136/jcp.33.9.871.
Serum immunoreactive trypsin (SIT) concentrations measured in 616 children with diabetes of recent onset were low, in both boys and girls, in comparison with reference ranges established in patients with non-diabetic, non-infectious illnesses. The mean SIT concentration was 60% of the mean reference level in children tested within three weeks of the onset of diabetes, and about 40% in patients tested six months after the onset of diabetes. Very low SIT levels were found in about 10% of patients, most of whom had no measurable SIT by the assay procedure employed. These very low SIT concentrations were more frequent in older children aged 6-15 years, and in children tested at about 5-6 months after onset. Repeat tests on some of the children showed that the very low SIT levels were generally present for only a limited period.
在616名近期发病的糖尿病儿童中测量的血清免疫反应性胰蛋白酶（SIT）浓度，与在非糖尿病、非感染性疾病患者中确定的参考范围相比，无论男孩还是女孩，其浓度都较低。在糖尿病发病后三周内接受检测的儿童中，SIT平均浓度为平均参考水平的60%，而在糖尿病发病六个月后接受检测的患者中，这一比例约为40%。在约10%的患者中发现SIT水平极低，其中大多数患者通过所采用的检测方法检测不到SIT。这些极低的SIT浓度在6至15岁的大龄儿童以及发病后约5至6个月接受检测的儿童中更为常见。对部分儿童的重复检测表明，极低的SIT水平通常仅在有限的时间段内出现。
