新生霉素对支原体病毒L2复制的影响。
Effect of novobiocin on mycoplasma virus L2 replication.
作者信息
Poddar S K, Maniloff J
出版信息
J Virol. 1984 Jan;49(1):283-6. doi: 10.1128/JVI.49.1.283-286.1984.
Abstract
L2 is a temperate mycoplasma virus containing 11.8 kilobase pairs of negatively superhelical double-stranded DNA. We observed L2 DNA with less superhelicity in novobiocin-treated cells than that in untreated cells. However, although no change in viral DNA superhelicity could be found in novobiocin-treated novobiocin-resistant cells, L2 production decreased in these novobiocin-treated cells.
摘要
L2是一种温和型支原体病毒，含有11.8千碱基对的负超螺旋双链DNA。我们观察到，与未用新生霉素处理的细胞相比，用新生霉素处理的细胞中L2 DNA的超螺旋程度较低。然而，尽管在用新生霉素处理的耐新生霉素细胞中未发现病毒DNA超螺旋程度有变化，但在这些用新生霉素处理的细胞中L2的产生减少了。
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