Hanssen L E
Scand J Gastroenterol. 1980;15(4):461-3. doi: 10.3109/00365528009181501.
When 20 ml of 50 mmol/l pure synthetic bile salts (pH 6.5), of approximately the same composition as human bile, were infused into the duodenum of six healthy volunteers over 5 min during constant gastric aspiration, plasma immunoreactive secretin increased from 2.5 +/- 0.4 pmol/l to 3.6 +/- 0.5 pmol/l at 10 min (p < 0.025). Gastric acid secretion was not increased. No effect was seen when the same amount of physiological saline was infused under the same conditions in another group. It is concluded that bile salts in an amount and composition corresponding to that in the human gallbladder is able to release immunoreactive secretin from the human intestine.
在持续胃抽吸过程中，将20毫升50毫摩尔/升、成分与人类胆汁大致相同（pH值6.5）的纯合成胆汁盐在5分钟内注入6名健康志愿者的十二指肠，在10分钟时血浆免疫反应性促胰液素从2.5±0.4皮摩尔/升升至3.6±0.5皮摩尔/升（p<0.025）。胃酸分泌未增加。在另一组相同条件下注入等量生理盐水时未观察到效果。结论是，数量和成分与人类胆囊胆汁相当的胆汁盐能够从人类肠道释放免疫反应性促胰液素。
