Kumami K, Mrsulja B B, Ueki Y, Djuricić B D, Spatz M
Laboratory of Neuropathology and Neuroanatomical Sciences, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20892.
Metab Brain Dis. 1988 Dec;3(4):273-7. doi: 10.1007/BF00999537.
Relationships between ischemic changes in the cerebral cortical content of energy and noradrenergic metabolites were evaluated in young and adult gerbils. Groups of 3-week- and 3-month-old gerbils were subjected to 5 or 15 min of bilateral carotid artery occlusion alone or with 1 hr of release. Ischemia of 5 and 15 min depleted energy-related metabolites but did not affect the content of either norepinephrine or homovanillic acid in young and adult gerbils. At 1 h of reflow, after 5 and 15 min of ischemia, the levels of norepinephrine significantly decreased, while those of homovanillic acid increased in the adult but not in the young gerbils. At this time a complete recovery of energy reserves was seen in both the young and the adult gerbils. These results indicate that the ischemic change in homeostasis of energy metabolism is not directly associated with that of the noradrenergic system in young and adult cerebral cortex.
在幼年和成年沙鼠中评估了大脑皮质能量含量与去甲肾上腺素能代谢产物缺血性变化之间的关系。将3周龄和3月龄的沙鼠分组，分别单独进行5或15分钟的双侧颈动脉闭塞，或先闭塞再松开1小时。5分钟和15分钟的缺血使能量相关代谢产物耗竭，但对幼年和成年沙鼠的去甲肾上腺素或高香草酸含量均无影响。在缺血5分钟和15分钟后的再灌注1小时时，成年沙鼠去甲肾上腺素水平显著下降，而高香草酸水平升高，幼年沙鼠则不然。此时，幼年和成年沙鼠的能量储备均完全恢复。这些结果表明，幼年和成年大脑皮质中能量代谢稳态的缺血性变化与去甲肾上腺素能系统的变化没有直接关联。
