替代雌激素与乳腺癌。

Replacement estrogens and breast cancer.

作者信息

Jick H, Walker A M, Watkins R N, D'Ewart D C, Hunter J R, Danford A, Madsen S, Dinan B J, Rothman K J

出版信息

Am J Epidemiol. 1980 Nov;112(5):586-94. doi: 10.1093/oxfordjournals.aje.a113031.

DOI:10.1093/oxfordjournals.aje.a113031

Abstract

The relation between replacement estrogens and breast cancer in menopausal women (age 45-64 years) was evaluated in the Group Health Cooperative of Puget Sound, Washington State, a prepaid health care organization with fully computerized information on outpatient drug use and hospital diagnoses. Little association between current estrogen use and breast cancer was noted in women with a previous hysterectomy (relative risk (RR) = 1.1; 90% confidence interval (Cl), 0.7-1.8). In women with a natural menopause there was a positive association between current estrogen use and breast cancer (RR = 3.4; 90% Cl, 2.1-5.6). This association was strong in naturally menopausal women aged 45-54 years (RR = 10.2) and weaker in the older age group (RR = 1.9).

摘要

在华盛顿州普吉特海湾地区的Group Health Cooperative（一家拥有门诊用药和医院诊断全面计算机化信息的预付医疗保健机构）中，评估了绝经后女性（45 - 64岁）中替代雌激素与乳腺癌之间的关系。在既往有子宫切除术的女性中，当前使用雌激素与乳腺癌之间几乎没有关联（相对风险（RR）= 1.1；90%置信区间（Cl），0.7 - 1.8）。在自然绝经的女性中，当前使用雌激素与乳腺癌之间存在正相关（RR = 3.4；90% Cl，2.1 - 5.6）。这种关联在45 - 54岁的自然绝经女性中很强（RR = 10.2），而在年龄较大的组中较弱（RR = 1.9）。