一种合成佐剂及其类似物对免疫反应的调节作用。
Modulation of the immune response by a synthetic adjuvant and analogs.
作者信息
Chedid L, Audibert F, Lefrancier P, Choay J, Lederer E
出版信息
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2472-5. doi: 10.1073/pnas.73.7.2472.
Abstract
N-Acetylmuramyl-L-alanyl-D-isoglutamine increases the humoral immune response of mice when given in aqueous media instead of the usual water-in-oil emulsions. Moreover, this compound is adjuvant active even by the oral route. In view of studying the relation between chemical structure and biological activity, several synthetic analogs were tested. The immune response could be modulated according to chemical modifications, and the synthetic analog with D- in place of L-alanine was shown to inhibit the immune response.
摘要
N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺以水性介质而非通常的油包水乳剂给药时，可增强小鼠的体液免疫反应。此外，该化合物即使经口服途径也具有佐剂活性。鉴于研究化学结构与生物活性之间的关系，对几种合成类似物进行了测试。免疫反应可根据化学修饰进行调节，并且显示用D-取代L-丙氨酸的合成类似物可抑制免疫反应。
相似文献
1
Modulation of the immune response by a synthetic adjuvant and analogs.一种合成佐剂及其类似物对免疫反应的调节作用。
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2472-5. doi: 10.1073/pnas.73.7.2472.
2
Enhancement of the neonate's nonspecific immunity to Klebsiella infection by muramyl dipeptide, a synthetic immunoadjuvant.合成免疫佐剂胞壁酰二肽增强新生儿对克雷伯菌感染的非特异性免疫力。
Proc Natl Acad Sci U S A. 1978 Jul;75(7):3395-9. doi: 10.1073/pnas.75.7.3395.
3
Influence of a synthetic adjuvant (MDP) on qualitative and quantitative changes of serum globulins.合成佐剂（MDP）对血清球蛋白定性和定量变化的影响。
Immunology. 1978 Dec;35(6):963-70.
4
5
Relationship between chemical structure and adjuvant activity of some synthetic analogues of N-acetyl-muramyl-L-alanyl-D-isoglutamine (MDP).N-乙酰基-胞壁酰-L-丙氨酰-D-异谷氨酰胺（MDP）某些合成类似物的化学结构与佐剂活性之间的关系
Ann Immunol (Paris). 1977 Apr-Jun;128C(3):653-61.
6
7
8
Immunoadjuvant effects of the synthetic muramyl-dipeptide (MDP) N-acetylmuramyl-L-alanyl-D-isoglutamine.合成的胞壁酰二肽（MDP）N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺的免疫佐剂作用。
Z Immunitatsforsch Immunobiol. 1978 Oct;155(1):87-92.
9
Kinetics of the humoral and cellular immune response of guinea pigs after injection of the synthetic adjuvant N-acetylmuramyl L-alanyl-D-isoglutamine: comparison with Freund complete adjuvant.豚鼠注射合成佐剂N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺后体液免疫和细胞免疫反应的动力学：与弗氏完全佐剂的比较
Infect Immun. 1978 Mar;19(3):966-71. doi: 10.1128/iai.19.3.966-971.1978.
10
Efficient genetically controlled formation of antibody to a synthetic antigen [poly(LTyr, LGlu)-poly(DLAla)- -poly(LLys)] covalently bound to a synthetic adjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine).高效地通过基因控制形成针对与合成佐剂（N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺）共价结合的合成抗原[聚（L-酪氨酸，L-谷氨酸）-聚（D-丙氨酸）-聚（L-赖氨酸）]的抗体。
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4933-7. doi: 10.1073/pnas.77.8.4933.
引用本文的文献
1
Structure-activity relationship in NOD2 agonistic muramyl dipeptides.NOD2 激动型 muramyl dipeptides 的结构-活性关系。
Eur J Med Chem. 2024 May 5;271:116439. doi: 10.1016/j.ejmech.2024.116439. Epub 2024 Apr 20.
2
Vaccine adjuvants: current status, research and development, licensing, and future opportunities.疫苗佐剂：现状、研究与开发、许可和未来机遇。
J Mater Chem B. 2024 May 1;12(17):4118-4137. doi: 10.1039/d3tb02861e.
3
Structural Fine-Tuning of Desmuramylpeptide NOD2 Agonists Defines Their Adjuvant Activity.结构精细调整脱酰基肽 NOD2 激动剂定义了它们的佐剂活性。
J Med Chem. 2021 Jun 10;64(11):7809-7838. doi: 10.1021/acs.jmedchem.1c00644. Epub 2021 May 27.
4
Pathogenic Chlamydia Lack a Classical Sacculus but Synthesize a Narrow, Mid-cell Peptidoglycan Ring, Regulated by MreB, for Cell Division.致病性衣原体缺乏经典的细胞壁，但能合成一个狭窄的、位于细胞中部的肽聚糖环，该环由MreB调控，用于细胞分裂。
PLoS Pathog. 2016 May 4;12(5):e1005590. doi: 10.1371/journal.ppat.1005590. eCollection 2016 May.
5
A cell-based microarray to investigate combinatorial effects of microparticle-encapsulated adjuvants on dendritic cell activation.一种基于细胞的微阵列，用于研究微粒包裹佐剂对树突状细胞激活的联合效应。
J Mater Chem B. 2016 Mar 7;4(9):1672-1685. doi: 10.1039/C5TB01754H. Epub 2015 Sep 30.
6
Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants.释放NOD样和Toll样激动剂作为疫苗佐剂的潜力。
Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12294-9. doi: 10.1073/pnas.1400478111. Epub 2014 Aug 18.
7
Effect of muramyl peptides on mitochondrial respiration.胞壁酰肽对线粒体呼吸的影响。
Clin Exp Immunol. 2009 Jan;155(1):72-8. doi: 10.1111/j.1365-2249.2008.03794.x.
8
9
Molecular mimicry revisited: gut bacteria and multiple sclerosis.再谈分子模拟：肠道细菌与多发性硬化症
J Clin Microbiol. 2006 Jun;44(6):2099-104. doi: 10.1128/JCM.02532-05.
10
Effects of treatment with muramyl dipeptide and certain of its analogs on resistance to Listeria monocytogenes in mice.用胞壁酰二肽及其某些类似物治疗对小鼠抗单核细胞增生李斯特菌能力的影响。
Infect Immun. 1980 Nov;30(2):462-6. doi: 10.1128/iai.30.2.462-466.1980.
本文引用的文献
1
A hydrosoluble, adjuvant-active mycobacterial "polysaccharide-peptidoglycan". Preparation by a simple extraction technique of the bacterial cells (strain Peurois).一种水溶性、具有佐剂活性的分枝杆菌“多糖 - 肽聚糖”。通过对细菌细胞（菌株Peurois）采用简单提取技术制备。
FEBS Lett. 1972 Sep 15;25(2):301-304. doi: 10.1016/0014-5793(72)80509-x.
2
Preparation and biological properties of water-soluble adjuvant fractions from delipidated cells of Mycobacterium smegmatis and Nocardia opaca.耻垢分枝杆菌和不透明诺卡氏菌脱脂细胞水溶性佐剂组分的制备及其生物学特性
Infect Immun. 1973 Jun;7(6):855-61. doi: 10.1128/iai.7.6.855-861.1973.
3
Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives.细菌肽聚糖衍生物佐剂活性的最小结构要求。
Biochem Biophys Res Commun. 1974 Aug 19;59(4):1317-25. doi: 10.1016/0006-291x(74)90458-6.
4
Genetic control of host responses to endotoxin.宿主对内毒素反应的遗传控制。
Infect Immun. 1972 Jan;5(1):107-13. doi: 10.1128/iai.5.1.107-113.1972.
5
Peptidoglycan types of bacterial cell walls and their taxonomic implications.细菌细胞壁的肽聚糖类型及其分类学意义。
Bacteriol Rev. 1972 Dec;36(4):407-77. doi: 10.1128/br.36.4.407-477.1972.
6
Water-soluble and lipid-free fraction from BCG with adjuvant and antitumour activity.具有佐剂和抗肿瘤活性的卡介苗水溶性无脂级分。
Nat New Biol. 1972 Aug 23;238(86):241-2. doi: 10.1038/newbio238241a0.
7
Isolation and properties of a macromolecular, water-soluble, immuno-adjuvant fraction from the cell wall of Mycobacterium smegmatis.耻垢分枝杆菌细胞壁中一种大分子、水溶性免疫佐剂组分的分离与特性
Proc Natl Acad Sci U S A. 1972 Apr;69(4):851-4. doi: 10.1073/pnas.69.4.851.
8
The wall peptidoglycans of Neisseria perflava, Moraxella glucidolytica, Pseudomonas alcaligenes and Proteus vulgaris strain P18.黄褐奈瑟菌、解糖莫拉菌、产碱假单胞菌和普通变形杆菌P18菌株的细胞壁肽聚糖。
Eur J Biochem. 1973 Oct 5;38(2):301-6. doi: 10.1111/j.1432-1033.1973.tb03062.x.
9
10
Distinctive adjuvanticity of synthetic analogs of mycobacterial water-soluble components.分枝杆菌水溶性成分合成类似物的独特佐剂活性。
Cell Immunol. 1976 Feb;21(2):243-9. doi: 10.1016/0008-8749(76)90053-8.
Zotero 插件