Chedid L, Audibert F, Lefrancier P, Choay J, Lederer E
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2472-5. doi: 10.1073/pnas.73.7.2472.
N-Acetylmuramyl-L-alanyl-D-isoglutamine increases the humoral immune response of mice when given in aqueous media instead of the usual water-in-oil emulsions. Moreover, this compound is adjuvant active even by the oral route. In view of studying the relation between chemical structure and biological activity, several synthetic analogs were tested. The immune response could be modulated according to chemical modifications, and the synthetic analog with D- in place of L-alanine was shown to inhibit the immune response.
N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺以水性介质而非通常的油包水乳剂给药时,可增强小鼠的体液免疫反应。此外,该化合物即使经口服途径也具有佐剂活性。鉴于研究化学结构与生物活性之间的关系,对几种合成类似物进行了测试。免疫反应可根据化学修饰进行调节,并且显示用D-取代L-丙氨酸的合成类似物可抑制免疫反应。