前列腺素与人类T淋巴细胞之间的相互作用：前列腺素E2对E受体表达的影响。

Interaction between prostaglandins and human T lymphocytes: effect of PGE2 on E-receptor expression.

作者信息

Venza-Teti D, Misefari A, Sofo V, Fimiani V, LaVia M F

出版信息

Immunopharmacology. 1980 Apr;2(2):165-71. doi: 10.1016/0162-3109(80)90009-0.

Abstract

E-rosette formation is not modified by preincubation of lymphocytes with prostaglandins (PGs) E1, F1 alpha, and F2 alpha. On the contrary, short preincubation with PGE2 affects active rosette-forming cells (Ea-RFC) and, only slightly, total RFC. This effect appears to be dose-dependent and relatively temperature-independent; it does not require calcium ions. Incubation with a fraction enriched in late RFC showed that PGE2 does not affect late rosette formation. It is postulated that PGE2 may redistribute surface receptors for sheep erythrocytes on T lymphocyte membranes. Thus, sensitivity to PGE2 may be considered another difference between early and late RFC.

摘要

淋巴细胞与前列腺素（PGs）E1、F1α和F2α预孵育后，E玫瑰花结形成未发生改变。相反，与PGE2短时间预孵育会影响活性玫瑰花结形成细胞（Ea-RFC），对总玫瑰花结形成细胞（RFC）的影响则较小。这种效应似乎呈剂量依赖性，且相对不依赖温度；它不需要钙离子。用富含晚期RFC的组分进行孵育表明，PGE2不影响晚期玫瑰花结形成。据推测，PGE2可能会使T淋巴细胞膜上绵羊红细胞的表面受体重新分布。因此，对PGE2的敏感性可被视为早期和晚期RFC之间的另一个差异。