Effect of ethanol on microsomal metabolism of dimethylnitrosamine.
作者信息
Schwarz M, Appel K E, Schrenk D, Kunz W
出版信息
J Cancer Res Clin Oncol. 1980;97(3):233-40. doi: 10.1007/BF00405774.
Abstract
Rat liver microsomes were prepared from male and female controls and from animals pretreated for 3 weeks with ethanol, and incubated with dimethylnitrosamine (DMN) and an NADPH-regenerating system. The formation of formaldehyde and nitrite as well as the alkylation of microsomal protein were found to be greatly enhanced, especially in the low DMN concentration range, as a result of long-term ethanol induction. In contrast, ethanol or tetrahydrofuran, when incubated simultaneously with DMN, inhibited microsomal metabolism of the carcinogen.
摘要
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