[非甾体抗炎药。V. 旋光性4-联苯氧基丁酸和4-联苯乙醇酸]
[Non-steroidal anti-inflammatory agents. V. Optically active 4-biphenylyloxybutyric and 4-biphenylylglycolic acids].
作者信息
Guarnieri A, Burnelli S, Andreani A, Busacchi I, Barbaro A M, Gaiardi M
出版信息
Farmaco Sci. 1978 Oct;33(10):761-9.
PMID:744235
Abstract
The synthesis and the resolution of the enantiomers of (+/-)2-(4-biphenylyl)-4-oxybutyric and (+/-)4-(4-biphenylyl)-2-oxybutyric acids and the resolution of the enantiomers of (+/-)2-(4-biphenylyl)-2-oxybutyric and (+/-)4-biphenylylglycolic acids are described. The potassium salts of each enantiomer were submitted to preliminary assays of antiphlogistic activity.
摘要
描述了(±)2-(4-联苯基)-4-氧代丁酸和(±)4-(4-联苯基)-2-氧代丁酸对映体的合成与拆分，以及(±)2-(4-联苯基)-2-氧代丁酸和(±)4-联苯基乙醇酸对映体的拆分。将每种对映体的钾盐进行了抗炎活性的初步测定。
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