[非甾体抗炎药。VI. 光学活性的3-(4-联苯基)-3-氧代丁酸、缬草酸、己酸和异己酸]
[Non-steroidal anti-inflammatory agents. VI. Optically active 3-(4-biphenylyl)-3-oxybutyric, valerianic, caproic and isocaproic acids].
作者信息
Guarnieri A, Burnelli S, Varoli L, Barbaro A M, Gaiardi M
出版信息
Farmaco Sci. 1978 Dec;33(12):992-8.
PMID:744247
Abstract
The synthesis of the (+/-) 3-(4-biphenylyl)-3-hydroxybutanoic, pentanoic, hexanoic and isohexanoic acids, and their resolution in to enantiomers are described. The latter were submitted to preliminary assay for antiinflammatory activity: interesting results were obtained above all for the isohexanoic acid derivative.
摘要
描述了（±）3-（4-联苯基）-3-羟基丁酸、戊酸、己酸和异己酸的合成及其拆分为对映体的过程。后者进行了抗炎活性的初步测定：尤其是异己酸衍生物获得了有趣的结果。
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