Glaser B M, D'Amore P A, Seppa H, Seppa S, Schiffmann E
Nature. 1980 Dec 4;288(5790):483-4. doi: 10.1038/288483a0.
New blood vessel formation, or angiogenesis, occurs through the migration of endothelial cells in elongated sprouts. These sprouts are directed preferentially towards the inciting stimulus. Several studies have demonstrated that certain chemical substances can stimulate angiogenesis. In these cases, endothelial cell migration towards the chemical stimulus may be due to a preferential migration of cells from lower to higher concentrations of the mediator. Such concentration gradient-dependent cellular migration has been termed chemotaxis. Using a modification of the Boyden chamber technique to measure chemotaxis in vitro, we have now found that extracts of various adult bovine tissues have potent chemotactic activity for vascular endothelial cells. Adult bovine serum lacks similar chemotactic activity.
新血管形成，即血管生成，是通过内皮细胞在细长芽中的迁移而发生的。这些芽优先朝向刺激物生长。多项研究表明，某些化学物质可刺激血管生成。在这些情况下，内皮细胞向化学刺激物的迁移可能是由于细胞从较低浓度的介质向较高浓度的介质优先迁移。这种浓度梯度依赖性细胞迁移被称为趋化性。我们采用改良的博伊登小室技术在体外测量趋化性，现已发现各种成年牛组织的提取物对血管内皮细胞具有强大的趋化活性。成年牛血清缺乏类似的趋化活性。
