Fayolle F, Privitera G, Sebald M
Antimicrob Agents Chemother. 1980 Oct;18(4):502-5. doi: 10.1128/AAC.18.4.502.
In susceptible strain of Bacteroides fragilis, tetracycline uptake is biphasic. The initial phase is independent of adenosine 5'-triphosphate synthesis, which is coupled to fumarate reduction; this phase is not altered by expression of tetracycline resistance genes in a resistant strain. The second phase appears to occur by active transport, since it is largely reduced by rotenone, an inhibitor of electron transport to fumarate; moreover, this phase is under negative control of the tetracycline resistance gene.
在脆弱拟杆菌的敏感菌株中，四环素摄取是双相的。初始阶段与腺苷5'-三磷酸合成无关，而腺苷5'-三磷酸合成与富马酸还原偶联；该阶段在抗性菌株中不受四环素抗性基因表达的影响。第二阶段似乎是通过主动转运发生的，因为它在很大程度上被鱼藤酮（一种向富马酸进行电子传递的抑制剂）所抑制；此外，该阶段受四环素抗性基因的负调控。
