Girs E F, Zubriakov S V, Kopylov V N, Saliaev V N, Titov N S
Farmakol Toksikol. 1980 May-Jun;43(3):280-4.
It was established in albino rats that the activity of the processes that are responsible for the functioning of the metabolic link in noradrenaline synthesis varies under ether and ftorotan anesthesia. It was recorded that there is an increase in the activity of DOPA decarboxylation in the brain under deep ether anesthesia as well as in the activity of dopamine decarboxylation during egress from anesthesia. Ftorotan anesthesia is characterized by increased hydroxylation of phenylalanine and decarboxylation of DOPA, and by inhibition of the activity of tyrosine and dopamine hydroxylation. Egress of animals from ftorotan anesthesia is associated with an intensive noradrenaline formation in the brain.
在白化大鼠中已证实,负责去甲肾上腺素合成代谢环节功能的过程的活性,在乙醚和氟烷麻醉下会发生变化。据记录,深度乙醚麻醉时大脑中多巴脱羧酶的活性增加,以及麻醉苏醒过程中多巴胺脱羧酶的活性增加。氟烷麻醉的特征是苯丙氨酸羟化增加和多巴脱羧,以及酪氨酸和多巴胺羟化活性受到抑制。动物从氟烷麻醉中苏醒与大脑中去甲肾上腺素的大量生成有关。