Idova G V, Cheĭdo M A
Biull Eksp Biol Med. 1987 Apr;103(4):440-2.
The role of serotonin receptors in the inhibitory effect of serotoninergic system on immunogenesis was studied using cyproheptadine, a specific blocker of 5-HT2 receptors. It was shown that cyproheptadine administration to CBA mice stimulated the immune response, which was dopamine-dependent and was realized via thymus. With the pituitary stalk destruction, the stimulatory effect of cyproheptadine was not observed, which suggests the participation of 5-HT2 brain receptors in immunogenesis.
使用5-HT2受体的特异性阻滞剂赛庚啶，研究了血清素受体在血清素能系统对免疫发生的抑制作用中的作用。结果表明，给CBA小鼠注射赛庚啶可刺激免疫反应，该反应依赖多巴胺并通过胸腺实现。垂体柄破坏后，未观察到赛庚啶的刺激作用，这表明5-HT2脑受体参与了免疫发生。
