Sturrock R R
Neuropathol Appl Neurobiol. 1980 Nov-Dec;6(6):415-20. doi: 10.1111/j.1365-2990.1980.tb00219.x.
Myelination has been studied in th corpus callosum of the mouse brain between birth and 240 days-of-age. Myelin sheaths were first seen at 11 days. The most rapid phase of myelination occurred between 14 and 45 days when 13.5% of axons were myelinated, but myelination continued at a reduced rate up to 240 days when 28% of axons were myelinated. The mean diameter of unmyelinated axons was more or less constant throughout the study with an overall mean diameter of 0.25 +/- 0.01 micron. Similarly myelinated axon diameter showed little variation with age with a mean diameter of 0.46 +/- 0.01 micron. This suggests that in the corpus callosum axons do not increase in size until they begin to myelinate.
研究了出生至240日龄小鼠脑胼胝体中的髓鞘形成情况。髓鞘在11日龄时首次出现。髓鞘形成最快速的阶段发生在14至45日龄之间，此时13.5%的轴突已形成髓鞘，但髓鞘形成以较低速率持续至240日龄，此时28%的轴突已形成髓鞘。在整个研究过程中，无髓鞘轴突的平均直径大致恒定，总体平均直径为0.25±0.01微米。同样，有髓鞘轴突的直径随年龄变化不大，平均直径为0.46±0.01微米。这表明在胼胝体中，轴突在开始形成髓鞘之前大小不会增加。
