Müller W, Klein P J, Vierbuchen M J, Uhlenbruck G
Neurosurg Rev. 1980;3(1):57-65. doi: 10.1007/BF01644420.
The surface of the cells of the normal choroid plexus and of the plexus papillomas is coated by sialomucopolysaccharides, containing substances which are positively stained with the colloidal iron (Hale-) reaction. After pretreatment with neuraminidase sialic acid is removed rendering the membrane negative to the Hale reaction. Using FITC- or rhodamine-labelled PNA (Arachis hypogaea) and RCA (Rhicinus communis) lectins specific receptors are demonstrable. The identity of these distinct oligosaccharides containing receptors with the Thomsen-Friedenreich antigens suggests the possibility of an immunologic significance, e. g. in bacterial or viral infections of the brain. The application of histochemical techniques seem suitable to clarify the differential-diagnosis between choroid plexus papillomas on the one hand and metastasis of carcinoma and papillary ependymomas on the other hand.
正常脉络丛和脉络丛乳头状瘤细胞的表面覆盖有唾液酸粘多糖，其中含有的物质可被胶体铁（黑尔氏）反应阳性染色。用神经氨酸酶预处理后，唾液酸被去除，使得细胞膜对黑尔氏反应呈阴性。使用异硫氰酸荧光素或罗丹明标记的花生凝集素（花生）和蓖麻凝集素（蓖麻）可显示特异性受体。这些含有不同寡糖的受体与汤姆森 - 弗里德赖希抗原的一致性表明了其具有免疫意义的可能性，例如在脑部细菌或病毒感染中。组织化学技术的应用似乎适合于阐明脉络丛乳头状瘤与癌转移及乳头状室管膜瘤之间的鉴别诊断。
