Gorczynski R M, MacRae S
Br J Cancer. 1981 Jan;43(1):32-43. doi: 10.1038/bjc.1981.5.
Tumour-cell growth in lung nodules after i.v. transfer to sublethally irradiated mice has been followed after adoptive transfer of different populations of lymphoid cells. Spleen cells deliberately immunized in vitro and in vivo against stimulator cells bearing embryo-associated antigens and which are cytostatic in vitro for targets bearing such antigens, can diminish the number of lung nodules found after i.v. transfer. In contrast, cytotoxic (in vitro) spleen cells, while capable of diminishing local (s.c.) growth of tumour cells, cannot control systemic tumour growth. Within a given solid tumour mass, the subpopulations resistant to cytostatic effector cells in vitro are the ones most likely to produce lung colonies after adoptive transfer in vivo, though they show no more local (s.c.) growth than to cytostatic-sensitive cells in vivo.
将不同群体的淋巴细胞进行过继转移后，对静脉注射到亚致死剂量照射小鼠体内的肺结节中的肿瘤细胞生长情况进行了跟踪研究。在体外和体内特意针对携带胚胎相关抗原的刺激细胞进行免疫的脾细胞，这些刺激细胞在体外对携带此类抗原的靶细胞具有细胞抑制作用，能够减少静脉注射后发现的肺结节数量。相比之下，具有细胞毒性（体外）的脾细胞虽然能够减少肿瘤细胞的局部（皮下）生长，但无法控制全身肿瘤生长。在给定的实体瘤块内，体外对细胞抑制效应细胞具有抗性的亚群在体内过继转移后最有可能产生肺集落，尽管它们在体内的局部（皮下）生长并不比细胞抑制敏感细胞更多。
