Hibbs J B
Science. 1973 May 25;180(4088):868-70. doi: 10.1126/science.180.4088.868.
Activated mouse macrophages were not cytotoxic to contact-inhibited nontumorigenic 3T3 fibroblasts, but caused marked destruction to non-contact-inhibited, tumorigenic 3T12 and simian virus 40-transformed fibroblasts. Nonimmunologic recognition and destruction of target cells by activated macrophages is independent of altered morphology, abnormal karyotype, and ability for continuous multiplication in vitro-all characteristics of 3T3 fibroblasts. A modification e f the target cell surface that results in a high in vitro saturation density, agglutinability by plant lectins, and tumorigenicity appears to evoke a cytotoxic response by activated macrophages.
活化的小鼠巨噬细胞对接触抑制的非致瘤性3T3成纤维细胞没有细胞毒性，但对非接触抑制的致瘤性3T12和猿猴病毒40转化的成纤维细胞造成了显著破坏。活化的巨噬细胞对靶细胞的非免疫识别和破坏与形态改变、核型异常以及体外连续增殖能力无关——这些都是3T3成纤维细胞的特征。靶细胞表面的一种修饰，导致高体外饱和密度、植物凝集素凝集性和致瘤性，似乎会引发活化巨噬细胞的细胞毒性反应。
