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抑郁症中的皮肤电活动:临床与生化关联

Electrodermal activity in depression: clinical and biochemical correlates.

作者信息

Mirkin A M, Coppen A

出版信息

Br J Psychiatry. 1980 Jul;137:93-7. doi: 10.1192/bjp.137.1.93.

DOI:10.1192/bjp.137.1.93
PMID:7459546
Abstract

Electrodermal activity was measured in a group of depressive patients and normal controls. Those patients classified as endogenous on the Newcastle Scale had significantly lower skin conductance levels than either the non-endogenous patients or controls. The endogenous depressives also contained significantly more non-responders to the experimental stimuli. The lack of responsiveness to external stimulation in non-responders is associated with a significantly lower rate of blood platelet 5-hydroxytryptamine uptake, suggesting that endogenous depressives have biological characteristics that distinguish them from other depressive groups and that electrodermal measures may be useful in the classification of depressive illness.

摘要

对一组抑郁症患者和正常对照组进行了皮肤电活动测量。在纽卡斯尔量表上被归类为内源性抑郁症的患者,其皮肤电导水平显著低于非内源性患者或对照组。内源性抑郁症患者中对实验刺激无反应者也明显更多。无反应者对外界刺激缺乏反应,这与血小板5-羟色胺摄取率显著降低有关,表明内源性抑郁症患者具有将他们与其他抑郁组区分开来的生物学特征,且皮肤电测量可能有助于抑郁症的分类。

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