Lishman A H, Al-Jumaili I J, Record C O
Gut. 1981 Jan;22(1):34-7. doi: 10.1136/gut.22.1.34.
In an attempt to find the extent to which Clostridium difficile could be implicated as the cause of antibiotic-associated diarrhoea, the stools of 53 patients who had diarrhoea after a course of antibiotics were investigated for the presence of C. difficile toxin. Ten of the patients (19%) were found to be positive, but the stools of four out of 53 patients without diarrhoea after a course of antibiotics were also found to contain C. difficile toxin (7.5%). The titre of toxin in patients both with and without diarrhoea fell within the same range (up to 10(-5)). Neither the organism nor its toxin was found in the stool of 26 patients with ulcerative colitis, eight with Crohn's disease, 49 with non-specific diarrhoea, and 27 normal controls. We conclude that, while C. difficile is responsible for a proportion of cases of antibiotic-associated diarrhoea, the concentration of toxin is not the sole factor affecting the severity of this disorder.
为了确定艰难梭菌在多大程度上可能是抗生素相关性腹泻的病因，对53例在使用一个疗程抗生素后出现腹泻的患者的粪便进行了艰难梭菌毒素检测。其中10例患者（19%）检测呈阳性，但在53例使用一个疗程抗生素后未出现腹泻的患者中，有4例的粪便也检测出含有艰难梭菌毒素（7.5%）。有腹泻和无腹泻患者的毒素滴度处于同一范围（高达10⁻⁵）。在26例溃疡性结肠炎患者、8例克罗恩病患者、49例非特异性腹泻患者和27例正常对照者的粪便中均未发现该菌及其毒素。我们得出结论，虽然艰难梭菌是一部分抗生素相关性腹泻病例的病因，但毒素浓度并非影响该疾病严重程度的唯一因素。
