新生儿艰难梭菌的发病率及来源
Incidence and origin of Clostridium difficile in neonates.
作者信息
Al-Jumaili I J, Shibley M, Lishman A H, Record C O
出版信息
J Clin Microbiol. 1984 Jan;19(1):77-8. doi: 10.1128/jcm.19.1.77-78.1984.
Abstract
The stools of 65 of 92 (71%) infants in a special care nursery yielded Clostridium difficile on culture. Ninety percent of stools collected after 6 to 35 days in the unit were positive, and 36% of these also contained toxin. When tested in vitro, 94% of the isolates produced toxin. Of 110 swabs collected from the environment of the unit, 9% were positive for C. difficile, but the stools of 12 nurses working on the unit were negative. Thirty-five vaginal swabs collected from mothers just before delivery were negative for C. difficile on culture, but 16 of their infants had C. difficile in their stools. It was concluded that there is a high carriage rate in the stools of neonates of C. difficile acquired progressively during the course of their stay in the special care unit. Infection is mainly from environmental sources rather than maternal transmission.
摘要
在一家特别护理托儿所的92名婴儿中，65名（71%）婴儿的粪便培养出艰难梭菌。在该机构住院6至35天后采集的粪便中，90%呈阳性，其中36%还含有毒素。体外测试时，94%的分离株产生毒素。从该机构环境中采集的110份拭子中，9%对艰难梭菌呈阳性，但在该机构工作的12名护士的粪便呈阴性。在分娩前从母亲那里采集的35份阴道拭子培养对艰难梭菌呈阴性，但她们的16名婴儿粪便中有艰难梭菌。得出的结论是，新生儿在特别护理病房住院期间，艰难梭菌在其粪便中的携带率很高，且是逐渐获得的。感染主要来自环境源而非母婴传播。
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