焦碳酸二乙酯与氨在体内可能形成致癌物质。
Possible in vivo formation of a carcinogenic substance from diethyl pyrocarbonate and ammonia.
作者信息
Uzvölgyi E, Boján F
出版信息
J Cancer Res Clin Oncol. 1980;97(2):205-7. doi: 10.1007/BF00409907.
Abstract
Development of lung tumors can be observed in Kid: CFLP mice treated intragastrically with diethyl pyrocarbonate and ammonia. The lung tumors may result from a carcinogenic substance, supposedly urethane, formed in vivo from diethyl pyrocarbonate in the presence of ammonia.
摘要
在用焦碳酸二乙酯和氨进行胃内给药处理的Kid:CFLP小鼠中可观察到肺肿瘤的发生。肺肿瘤可能是由一种致癌物质引起的，据推测是氨基甲酸乙酯，它是在氨存在的情况下由焦碳酸二乙酯在体内形成的。
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