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细胞表面与胚胎:F9畸胎瘤抗原在T区域致死、其他致死及正常着床前小鼠胚胎中的表达

Cell surfaces and embryos: expression of the F9 teratocarcinoma antigen in T-region lethal, other lethal, and normal pre-implantation mouse embryos.

作者信息

Erickson R P, Lewis S E

出版信息

J Reprod Immunol. 1980 Dec;2(5):293-304. doi: 10.1016/0165-0378(80)90042-x.

Abstract

F9 teratocarcinoma antigen is expressed normally on embryos which are homozygous recessive for each of 4 mutations lethal in early development, including t12. Homozygosity for two post-implantation T-region developmental lethal genes, tw5 and T0r1, may alter F9 antigen expression but the results were not definitive. In addition, the time of appearance of the antigen may be affected by some of the genotypes.

摘要

F9畸胎瘤抗原在早期发育中对4种致死突变(包括t12)均为纯合隐性的胚胎上正常表达。对于两个植入后T区域发育致死基因tw5和T0r1的纯合性可能会改变F9抗原的表达,但结果并不确定。此外,抗原出现的时间可能会受到某些基因型的影响。

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