Kemler R, Babinet C, Condamine H, Gachelin G, Guenet J L, Jacob F
Proc Natl Acad Sci U S A. 1976 Nov;73(11):4080-4. doi: 10.1073/pnas.73.11.4080.
The presence of the F9 antigen and of four other antigens related to the T/t locus of the mouse was investigated by immunofluorescence on preimplantation embryos. In morulae heterozygous for any of these t haplotypes, both the appropriate t antigen and the F9 antigen are expressed. The F9 antigen segregates among the progeny of crosses producing embryos homozygous for some (tw32 and tw5) but not for other haplotypes. It is concluded that (i) whatever the time of action of a t haplotype, its corresponding antigen is expressed during cleavage and (ii) the F9 antigen is specified by a gene(s) in the region of the T/t locus.
通过对植入前胚胎进行免疫荧光检测，研究了F9抗原以及与小鼠T/t位点相关的其他四种抗原的存在情况。在这些t单倍型中任何一种的桑椹胚杂合子中，相应的t抗原和F9抗原均有表达。F9抗原在产生某些（tw32和tw5）但不是其他单倍型纯合胚胎的杂交后代中发生分离。得出的结论是：（i）无论t单倍型的作用时间如何，其相应抗原在卵裂期间表达；（ii）F9抗原由T/t位点区域的一个或多个基因所决定。
