Shneerson J M
Thorax. 1978 Dec;33(6):747-54. doi: 10.1136/thx.33.6.747.
Pulmonary artery catheterisation was carried out in 25 scoliotics aged 13 to 67 years (mean 30.7). Each then performed a progressive exercise test breathing air, and 11 performed a similar test breathing pure oxygen. The mean pulmonary artery pressure (PAP) increased linearly with oxygen uptake (VO2) and with the work rate. The pressure responses have been described in terms of ther intercept and rate of rise of pressure (sPAP/VO2 and sPAP/work rate). sPAP/VO2 was unrelated to the anatomical features of the scoliosis, or to PaO2. It was inversely related to vital capacity, functional residual capacity, and total lung capacity. Inspiration of pure oxygen lowered the resting pressure by a mean of 3.2 mmHg but only decreased sPAP/work rate by 9%. The maximum pressure reached during exercise was diminished by a mean of 5.2 mmHg when pure oxygen was breathed. The mean pressures were shown to fall exponentially after exercise. The time constants were proportional to sPAP/VO2 and to the final pressure reached during exercise. Inspiration of pure oxygen did not effect the time constants but decreased the post-exercise pressure load by lowering the final pressure during exercise.
对25名年龄在13至67岁（平均30.7岁）的脊柱侧弯患者进行了肺动脉插管术。然后，每个人进行了渐进性运动试验，呼吸空气，其中11人进行了类似的呼吸纯氧试验。平均肺动脉压（PAP）随摄氧量（VO2）和工作负荷呈线性增加。压力反应已根据压力的截距和上升速率（sPAP/VO2和sPAP/工作负荷）进行描述。sPAP/VO2与脊柱侧弯的解剖特征或动脉血氧分压（PaO2）无关。它与肺活量、功能残气量和肺总量呈负相关。吸入纯氧使静息压力平均降低3.2 mmHg，但仅使sPAP/工作负荷降低9%。呼吸纯氧时，运动期间达到的最大压力平均降低5.2 mmHg。运动后平均压力呈指数下降。时间常数与sPAP/VO2以及运动期间达到的最终压力成正比。吸入纯氧不影响时间常数，但通过降低运动期间的最终压力来减轻运动后压力负荷。
