Davis Mellar P, Walsh Declan, Lagman Ruth, Yavuzsen Tugba
The Harry R Horvitz Center For Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA.
Support Care Cancer. 2006 Jul;14(7):693-8. doi: 10.1007/s00520-005-0015-4. Epub 2006 Apr 20.
The severity of anorexia correlates with the presence of early satiety. The sense of fullness limits nutritional intake. The symptom is poorly understood because most assessment questionnaires do not include early satiety.
Patients rarely volunteer early satiety. Central and peripheral mechanisms may be involved in the genesis of early satiety. These would include central sensory specific satiety, food aversions, diurnal changes in intake, gastric motility and accommodation and as gastrointestinal hormones.
Prokinetic medications, such as metoclopramide are used to treat early satiety. However, other medications which influence gastric accommodation such as clonidine, sumatriptan, or sildenafil, or diminish enteric afferent output such as kappa opioid receptor agonists, may favorably influence early satiety and should be subject to future research. Translational research is needed to understand the relationship of early satiety to gastric motility and accommodation.
厌食症的严重程度与早饱感的存在相关。饱腹感限制了营养摄入。由于大多数评估问卷未包括早饱感，因此对该症状的了解甚少。
患者很少主动提及早饱感。中枢和外周机制可能参与了早饱感的产生。这些机制包括中枢感觉特异性饱腹感、食物厌恶、摄入量的昼夜变化、胃动力和容纳功能以及胃肠激素。
促动力药物，如甲氧氯普胺，用于治疗早饱感。然而，其他影响胃容纳功能的药物，如可乐定、舒马曲坦或西地那非，或减少肠传入输出的药物，如κ阿片受体激动剂，可能对早饱感有积极影响，应进行进一步研究。需要进行转化研究以了解早饱感与胃动力和容纳功能之间的关系。
