Ramwell P W
Arch Intern Med. 1981 Feb 23;141(3 Spec No):275-8. doi: 10.1001/archinte.141.3.275.
The most abundant prostaglandin precursor is arachidonic acid (or its precursor, linoleic acid). The isolation and identification of prostaglandin compounds in a particular tissue, knowledge of the biologic properties of these compounds, and the use of readily available inhibitors of the prostaglandin pathway by aspirin-like drugs constitute the main steps in identifying the clinically significant arachidonic acid-prostaglandin systems. However, arachidonate-prostaglandin products are still difficult to measure clinically. The inhibitory effect of hydrocortisone on slow-reacting substance of anaphylaxis production can be partly reversed by arachidonic acid, which may explain aspirin- and indomethacin-sensitive asthma. Acetaminophen, when coadministered orally with aspirin and indomethacin, prevents gastric erosion. Long-acting prostaglandin analogues are currently used in obstetrics and are being tested in the treatment of thrombosis, inflammation, and excessive gastric acid secretion.
最丰富的前列腺素前体是花生四烯酸（或其前体亚油酸）。在特定组织中分离和鉴定前列腺素化合物、了解这些化合物的生物学特性以及使用阿司匹林类药物对前列腺素途径的现成抑制剂，是确定临床上重要的花生四烯酸 - 前列腺素系统的主要步骤。然而，花生四烯酸 - 前列腺素产物在临床上仍难以测量。氢化可的松对过敏反应慢反应物质产生的抑制作用可被花生四烯酸部分逆转，这可能解释了对阿司匹林和吲哚美辛敏感的哮喘。对乙酰氨基酚与阿司匹林和吲哚美辛口服合用时，可预防胃糜烂。长效前列腺素类似物目前用于产科，并且正在进行治疗血栓形成、炎症和胃酸分泌过多的试验。
