一种微粒体制剂可从花生四烯酸生成兔主动脉收缩物质（RCS），该制剂也能生成前列腺素。
The generation from arachidonic acid of rabbit aorta contracting substance (RCS) by a microsomal enzyme preparation which also generates prostaglandins.
作者信息
Gryglewski R, Vane J R
出版信息
Br J Pharmacol. 1972 Nov;46(3):449-57. doi: 10.1111/j.1476-5381.1972.tb08142.x.
Abstract
- Sodium arachidonate was incubated with a crude prostaglandin synthetase preparation made from dog spleen. The incubation was made in a dynamic system so that the products could be delivered to strips of rabbit aorta and rat stomach.2. A rabbit aorta contracting substance (RCS) and a prostaglandin-like substance were formed. The RCS had similar properties to that released in anaphylaxis. It was unstable and as the RCS activity declined, so the prostaglandin-like activity increased. Its formation was prevented by prostaglandin synthetase inhibitors such as indomethacin.3. A different rabbit aorta contracting substance was formed by incubation of arachidonate with lipoxygenase, which generates peroxides. This substance was stable and did not lead to prostaglandin production.4. We conclude that RCS may be an intermediate in prostaglandin production, such as the postulated cyclic endoperoxide.
摘要
将花生四烯酸钠与从狗脾脏制备的粗制前列腺素合成酶制剂一起孵育。孵育在动态系统中进行，以便产物能够被递送至兔主动脉条和大鼠胃条。
形成了一种兔主动脉收缩物质（RCS）和一种类前列腺素物质。该RCS具有与过敏反应中释放的物质相似的特性。它不稳定，随着RCS活性下降，类前列腺素活性增加。其形成可被吲哚美辛等前列腺素合成酶抑制剂阻止。
通过将花生四烯酸与产生过氧化物的脂氧合酶孵育，形成了一种不同的兔主动脉收缩物质。该物质稳定，不会导致前列腺素产生。
我们得出结论，RCS可能是前列腺素产生过程中的一种中间体，例如假定的环内过氧化物。
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The generation from arachidonic acid of rabbit aorta contracting substance (RCS) by a microsomal enzyme preparation which also generates prostaglandins.一种微粒体制剂可从花生四烯酸生成兔主动脉收缩物质（RCS），该制剂也能生成前列腺素。
Br J Pharmacol. 1972 Nov;46(3):449-57. doi: 10.1111/j.1476-5381.1972.tb08142.x.
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1
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Br J Pharmacol Chemother. 1957 Sep;12(3):344-9. doi: 10.1111/j.1476-5381.1957.tb00146.x.
2
On the specificity of the oxygenation of unsaturated fatty acids catalyzed by soybean lipoxidase.关于大豆脂氧化酶催化的不饱和脂肪酸氧化作用的特异性
J Biol Chem. 1967 Nov 25;242(22):5329-35.
3
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4
Release of vaso-active substances from lungs by injection of particles.通过注射颗粒从肺部释放血管活性物质。
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5
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6
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