Larsson L I, Childers S, Snyder S H
Nature. 1979 Nov 22;282(5737):407-10. doi: 10.1038/282407a0.
A pair of pentapeptides, Met- and Leu-enkephalin were recently isolated from brain tissue. The two peptides seem to represent endogenous opiate receptor ligands and have by immunocytochemical and radioimmunoassay studies been shown to occur in an extensive system of cerebral and peripheral nerves. The relative proportions between Met- and Leu-enkephalin varies between different brain regions and also between different species, suggesting the existence of separate populations of Met- and Leu-enkephalin nerves. Until now, however, immunocytochemistry has given no support for this notion. We report here evidence of separate populations of Met- and Leu-enkephalin nerves.
最近从脑组织中分离出一对五肽，即甲硫氨酸脑啡肽和亮氨酸脑啡肽。这两种肽似乎代表内源性阿片受体配体，免疫细胞化学和放射免疫分析研究表明它们存在于广泛的脑和外周神经系统中。甲硫氨酸脑啡肽和亮氨酸脑啡肽之间的相对比例在不同脑区以及不同物种之间有所不同，这表明存在不同的甲硫氨酸脑啡肽神经群体和亮氨酸脑啡肽神经群体。然而，到目前为止，免疫细胞化学尚未支持这一观点。我们在此报告存在不同的甲硫氨酸脑啡肽神经群体和亮氨酸脑啡肽神经群体的证据。
