Karlsen R L, Grofova I, Malthe-Sørenssen D, Fonnum F
Brain Res. 1981 Mar 9;208(1):167-80. doi: 10.1016/0006-8993(81)90628-4.
A single subcutaneous injection of L-cysteine (1.2 mg/g body weight) to rats 4 days after birth was followed by atrophy of the brain which was well developed 27--32 days after the injection. It was apparent that the lesioned animals could be divided into two groups (type 1 and 2) on account of the degree of brain atrophy. In type 1, which was observed in 80% of the animals, the body weight was unchanged, but the total brain weight was reduced by about 20%. The brain structures most affected were cerebral cortex, hippocampus and thalamus, each having a 30--40% reduction in wet weight. The atrophy of the posterior part of cortex was particularly pronounced in this type of lesion. In type 2 lesion, which appeared in 10% of the survivors, the atrophy was much more severe. There was a 50% reduction in wet weight of brain and in body weight. The most prominent finding was the atrophy of the whole cortex and the hippocampus which were reduced by 80 and 60% of wet weights respectively. In this type of lesion significant morphological changes were observed in several brain regions such as caudato-putamen, thalamus, pons, medulla oblongata, spinal cord and cerebellum.
出生后4天给大鼠皮下注射一次L-半胱氨酸（1.2毫克/克体重），随后大脑出现萎缩，在注射后27至32天萎缩情况严重。很明显，根据大脑萎缩程度，受损动物可分为两组（1型和2型）。在80%的动物中观察到的1型，体重未变，但大脑总重量减少了约20%。受影响最严重的脑结构是大脑皮层、海马体和丘脑，其湿重各减少了30%至40%。在这种类型的损伤中，皮层后部的萎缩尤为明显。在10%的存活者中出现的2型损伤，萎缩更为严重。脑湿重和体重减少了50%。最显著的发现是整个皮层和海马体萎缩，其湿重分别减少了80%和60%。在这种类型的损伤中，在几个脑区如尾状核-壳核、丘脑、脑桥、延髓、脊髓和小脑中观察到了明显的形态学变化。
