Tagnon I, Blot W J, Stroube R B, Day N E, Morris L E, Peace B B, Fraumeni J F
Cancer Res. 1980 Nov;40(11):3875-9.
A case-control study was undertaken to clarify reasons for a four-fold increased incidence of mesothelioma discovered among white males in coastal Tidewater, Va., from 1972 to 1978. Sixty-one cases were identified. Interviews with next of kin revealed that the excess was linked to employment in area shipyards. Three-fourths of the cases had been employed in the shipbuilding industry, nearly all beginning employment prior to 1950. Most were career employees, but an increased risk was also found among those who worked only temporarily, mainly during World War II, and were reportedly exposed to asbestos. More of the cases than controls were pipecoverers or pipefitters, but cases were reported to work in a variety of shipyard trades. Few of the mesothelioma cases were heavy smokers, a trend that may be related in part to the competing risks for fatal diseases caused by the interactions of smoking and asbestos exposure. Information obtained by interview for five of the six white females diagnosed with mesothelioma revealed that the husband of four had been employed in the shipbuilding industry.
开展了一项病例对照研究，以查明1972年至1978年期间弗吉尼亚州沿海潮汐地带白人男性间皮瘤发病率增加四倍的原因。共识别出61例病例。对近亲的访谈显示，发病率过高与该地区造船厂的工作有关。四分之三的病例曾受雇于造船业，几乎所有人在1950年之前就开始工作。大多数是长期雇员，但在那些仅临时工作的人中也发现风险增加，主要是在第二次世界大战期间，据报道他们接触过石棉。病例中管道包覆工或管道安装工比对照更多，但据报告病例从事各种造船厂行业。间皮瘤病例中很少有重度吸烟者，这一趋势可能部分与吸烟和接触石棉相互作用导致致命疾病的竞争风险有关。对6名被诊断为间皮瘤的白人女性中的5名进行访谈获得的信息显示，其中4人的丈夫曾受雇于造船业。
