Blot W J, Harrington J M, Toledo A, Hoover R, Heath C W, Fraumeni J F
N Engl J Med. 1978 Sep 21;299(12):620-4. doi: 10.1056/NEJM197809212991202.
A case-control study, undertaken to identify reasons for the exceptionally high rate of lung cancer among male residents of coastal Georgia, revealed a significantly increased risk associated with employment in area shipyards during World War II. The summary relative-risk estimate, adjusted for smoking, other occupations, age, race and county of residence was 1.6 (95 per cent confidence limits = 1.1 to 2.3). A synergistic relation was found between shipyard employment and cigarette smoking. These findings suggest that asbestos and possible other shipyard exposures during wartime employment account for part of the excess mortality from lung cancer in certain coastal areas of the United States.
一项病例对照研究旨在确定佐治亚州沿海地区男性居民肺癌发病率异常高的原因，该研究发现，二战期间在当地造船厂工作与肺癌风险显著增加有关。在对吸烟、其他职业、年龄、种族和居住县进行调整后，汇总相对风险估计值为1.6（95%置信区间=1.1至2.3）。研究发现造船厂工作与吸烟之间存在协同关系。这些发现表明，战时在造船厂工作期间接触石棉以及可能接触的其他物质，是美国某些沿海地区肺癌超额死亡率的部分原因。
