el-Hazmi M A, al-Swailem A R, Warsy A S, al-Swailem A M, Sulaimani R, al-Meshari A A
Department of Medical Biochemistry, King Khalid University Hospital, Riyadh, Saudi Arabia.
J Med Genet. 1995 Aug;32(8):623-6. doi: 10.1136/jmg.32.8.623.
This study was conducted on 3212 Saudi families to investigate the prevalence of consanguineous marriages. The families were interviewed and the information on the relationship between the husband and wife was obtained. The overall rate of consanguinity shows that 57.7% of the families screened were consanguineous. The most frequent were first cousin marriages (28.4%) followed by distant relative marriages (15.2%) and second cousin marriages (14.6%). The families were grouped according to the province of their origin and the consanguinity rates were calculated accordingly. There were slight differences in the consanguinity rates in the five provinces, which ranged from 52.1% to 67.7%. In each province first cousin marriages were the most frequently encountered pattern, ranging from 17.9% to 40.9%. The inbreeding coefficient (F) was calculated for each province and ranged from 0.020 to 0.030. Within each province, there were several significant differences among the populations in the different areas. The highest rate of consanguinity was 80.6% in Samtah and the lowest rate was around 34% in Abha in the South Western province. These results place Saudi Arabia among the countries of the world with a high rate of consanguinity. The possible consequences of increased consanguinity are presented and discussed.
本研究对3212个沙特家庭进行了调查，以探究近亲结婚的 prevalence。对这些家庭进行了访谈，并获取了夫妻关系的相关信息。近亲结婚的总体比例表明，接受筛查的家庭中有57.7%为近亲结婚。最常见的是表亲结婚（28.4%），其次是远亲结婚（15.2%）和二级表亲结婚（14.6%）。这些家庭根据其原籍省份进行分组，并据此计算近亲结婚率。五个省份的近亲结婚率略有差异，范围从52.1%到67.7%。在每个省份，表亲结婚都是最常见的模式，范围从17.9%到40.9%。计算了每个省份的近亲繁殖系数（F），范围从0.020到0.030。在每个省份内，不同地区的人群之间存在一些显著差异。近亲结婚率最高的是 Samtah，为80.6%，最低的是西南省份的阿卜哈，约为34%。这些结果使沙特阿拉伯跻身世界上近亲结婚率较高的国家之列。文中呈现并讨论了近亲结婚率上升可能带来的后果。
