Bieniasz P D, Weiss R A, McClure M O
Department of GU Medicine and Communicable Diseases, Jefferiss Research Trust, St. Mary's Hospital Medical School, London, United Kingdom.
J Virol. 1995 Nov;69(11):7295-9. doi: 10.1128/JVI.69.11.7295-7299.1995.
In common with oncoviruses but unlike the lentivirus human immunodeficiency virus type 1, foamy (spuma) viruses require host cell proliferation for productive infection. We show that human immunodeficiency virus type 1 replicates in RD-CD4 cells regardless of the growth arrest condition of the cells, while murine leukemia virus is unable to infect growth-arrested RD-CD4 cells or cells progressing through a partial cell cycle that includes S phase but not mitosis. Human foamy virus, like murine leukemia virus, does not productively infect G1/S or G2 growth-arrested cells. Two other foamy viruses, simian foamy virus type 1, isolated from a macaque, and simian foamy virus type 6, isolated from a chimpanzee, also fail to establish productive infection in G1/S-arrested cells.
与致瘤病毒相同，但与慢病毒1型人类免疫缺陷病毒不同，泡沫（泡沫状）病毒进行有效感染需要宿主细胞增殖。我们发现，无论细胞的生长停滞状态如何，1型人类免疫缺陷病毒都能在RD-CD4细胞中复制，而鼠白血病病毒无法感染生长停滞的RD-CD4细胞或经历包括S期但不包括有丝分裂的部分细胞周期的细胞。人类泡沫病毒与鼠白血病病毒一样，不能有效感染G1/S或G2期生长停滞的细胞。另外两种泡沫病毒，从猕猴分离出的1型猿猴泡沫病毒和从黑猩猩分离出的6型猿猴泡沫病毒，也无法在G1/S期停滞的细胞中建立有效感染。
