Takebe T, Takahashi S, Kagaya T, Ishizuki S, Hanawa M, Koizumi M, Kataoka S, Kamei T, Ohyama K, Endo K
Gastroenterol Jpn. 1978;13(6):447-60. doi: 10.1007/BF02774911.
When secretin was given by continuous intravenous infusion in the control subjects, the dose of secretin inducing maximal bicarbonate output was found to be around 6.0 CHR U/kg/hr. Then the pancreatic exocrine secretory response to sequential standard (1.2 CHR U/kg/hr) and augmented (6.0 CHR U/kg/hr) dose of secretin was studied in the controls, in patients with chronic pancreatitis and in its suspected cases. This new method for exocrine pancreatic function did not offer advantage for the diagnosis of well established chronic pancreatitis. But from the results obtained in suspected chronic pancreatitis it was supposed that the decline of increasing rate of bicarbonate output with augmentation of dose and the decrease of response to augmented dose of secretin might be one of functional disorders occurred in the early stage of chronic pancreatitis.
在对照受试者中通过持续静脉输注给予促胰液素时，发现诱导最大碳酸氢盐输出量的促胰液素剂量约为6.0 CHR U/kg/小时。然后，在对照组、慢性胰腺炎患者及其疑似病例中，研究了胰腺外分泌对连续标准剂量（1.2 CHR U/kg/小时）和增加剂量（6.0 CHR U/kg/小时）促胰液素的分泌反应。这种用于胰腺外分泌功能的新方法对确诊的慢性胰腺炎诊断并无优势。但从疑似慢性胰腺炎患者获得的结果推测，随着剂量增加碳酸氢盐输出增加率的下降以及对增加剂量促胰液素反应的降低，可能是慢性胰腺炎早期发生的功能障碍之一。
