Leitch A G, Rubilar M, Watt B, Laing R, Willcocks L, Brettle R P, Leen C L
Respiratory Medicine, Department of Medicine (RIE), University of Edinburgh, U.K.
Respir Med. 1995 Aug;89(7):495-7. doi: 10.1016/0954-6111(95)90125-6.
By December 1993, only five cases of tuberculosis were observed in the 1030 HIV-positive patients in Edinburgh, U.K., although, on the basis of historical tuberculin skin test data, between four and eight new cases of tuberculosis were expected per year. Of 310 HIV-positive patients, none of the 19 (6.1%) who were tuberculin skin test positive had developed tuberculosis after 87 months (average) of follow-up. It is suggested that new or re-infection is a more common cause of tuberculosis in HIV-positive patients than reactivation. Restriction fragment length polymorphism typing of Mycobacterium tuberculosis strains could confirm this hypothesis and support currently suggested additional infection control procedures.
到1993年12月，在英国爱丁堡的1030名艾滋病毒阳性患者中仅观察到5例结核病患者，尽管根据以往结核菌素皮肤试验数据，预计每年会出现4至8例新的结核病病例。在310名艾滋病毒阳性患者中，结核菌素皮肤试验呈阳性的19名患者（6.1%）在平均87个月的随访期后均未患结核病。有人提出，对于艾滋病毒阳性患者，新感染或再感染是导致结核病的更常见原因，而非结核杆菌再激活。对结核分枝杆菌菌株进行限制性片段长度多态性分型可以证实这一假设，并支持目前建议的额外感染控制措施。
