Rowe J E, St Jeor S C, Riolo J, Otteson E W, Monroe M C, Henderson W W, Ksiazek T G, Rollin P E, Nichol S T
Department of Microbiology, University of Nevada, Reno 89557, USA.
Virology. 1995 Oct 20;213(1):122-30. doi: 10.1006/viro.1995.1552.
Three genetically distinct members of the Hantavirus genus have been detected in Nevada rodents by RT-PCR and nucleotide sequence analysis. These include Sin Nombre (SN), El Moro Canyon (ELMC), and Prospect Hill (PH)-like viruses which are primarily associated with Peromyscus maniculatus (deer mouse), Reithrodontomys megalotis (western harvest mouse), and Microtus spp. (voles), respectively. Although this region of the United States is ecologically diverse, rodents infected with different hantaviruses appear to coexist in several different geographical and ecological zones. In two widely separated states, Nevada and North Dakota, PH-like viruses are present in three different species of vole. In addition, ELMC-like virus has been detected in both R. megalotis and M. montanus (mountain vole). SN virus is a cause of hantavirus pulmonary syndrome throughout much of the United States. SN virus RNA is found in 12.5% of P. maniculatus in Nevada and eastern California. Two lineages of SN virus coexist in this region and differ from SN viruses originally found in infected rodents in New Mexico, Arizona, and Colorado. These data show the complexity of hantavirus maintenance in rodents. Distinct hantaviruses or virus lineages can coexist either in different or the same rodent species and in either different or the same geographic or ecological zones.
通过逆转录聚合酶链反应（RT-PCR）和核苷酸序列分析，在内华达州的啮齿动物中检测到了汉坦病毒属的三个基因不同的成员。这些病毒包括辛诺柏（SN）病毒、埃尔莫罗峡谷（ELMC）病毒和类展望山（PH）病毒，它们分别主要与鹿鼠、西部收获鼠和田鼠属的田鼠相关。尽管美国的这个地区生态多样，但感染不同汉坦病毒的啮齿动物似乎在几个不同的地理和生态区域中共存。在内华达州和北达科他州这两个相距甚远的州，类PH病毒存在于三种不同的田鼠中。此外，在西部收获鼠和山地田鼠中都检测到了类ELMC病毒。SN病毒是美国大部分地区汉坦病毒肺综合征的病因。在内华达州和加利福尼亚州东部，12.5%的鹿鼠中发现了SN病毒RNA。该地区存在两种SN病毒谱系，它们与最初在新墨西哥州、亚利桑那州和科罗拉多州感染啮齿动物中发现的SN病毒不同。这些数据显示了汉坦病毒在啮齿动物中维持的复杂性。不同的汉坦病毒或病毒谱系可以在不同或相同的啮齿动物物种中，以及在不同或相同的地理或生态区域中共存。
