Song W, Torrez-Martinez N, Irwin W, Harrison F J, Davis R, Ascher M, Jay M, Hjelle B
Department of Pathology, University of New Mexico School of Medicine, Albuquerque 87131-5301, USA.
J Gen Virol. 1995 Dec;76 ( Pt 12):3195-9. doi: 10.1099/0022-1317-76-12-3195.
Prospect Hill virus (PH) was isolated from a meadow vole (Microtus pennsylvanicus) in 1982, and much of its genome has been sequenced. Hantaviruses of other New World microtine rodents have not been genetically characterized. We show that another Microtus species (the California vole M. californicus) from the United States is host to a genetically distinct PH-like hantavirus, Isla Vista virus (ILV). The nucleocapsid protein of ILV differs from that of PH by 11.1% and a portion of the G2 glycoprotein differs from that of PH by 19.6%. ILV antibodies were identified in five of 33 specimens of M. californicus collected in 1975 and 1994-1995. Enzymatic amplification studies showed that 1975 and 1994-1995 ILV genomes were highly similar. Secondary infection of Peromyscus californicus was identified in Santa Barbara County, California. A long-standing enzootic of a genetically distinct hantavirus lineage is present in California voles.
展望山病毒（PH）于1982年从一只草甸田鼠（宾夕法尼亚田鼠）中分离出来，其大部分基因组已被测序。其他新大陆田鼠啮齿动物的汉坦病毒尚未进行基因特征分析。我们发现，来自美国的另一种田鼠物种（加利福尼亚田鼠）是一种基因上不同的类PH汉坦病毒——伊斯拉维斯塔病毒（ILV）的宿主。ILV的核衣壳蛋白与PH的核衣壳蛋白有11.1%的差异，G2糖蛋白的一部分与PH的G2糖蛋白有19.6%的差异。在1975年以及1994 - 1995年采集的33份加利福尼亚田鼠标本中，有5份检测出了ILV抗体。酶促扩增研究表明，1975年和1994 - 1995年的ILV基因组高度相似。在加利福尼亚州圣巴巴拉县发现了加州白足鼠的二次感染情况。在加利福尼亚田鼠中存在一种基因上不同的汉坦病毒谱系的长期地方性流行。
