皮肤患者中金黄色葡萄球菌对抗生素耐药性的获得
Acquisition of antibiotic resistance by Staphylococcus aureus in skin patients.
作者信息
Naidoo J, Noble W C
出版信息
J Clin Pathol. 1978 Dec;31(12):1187-92. doi: 10.1136/jcp.31.12.1187.
Acquisition of resistance to neomycin, gentamicin, fusidic acid, or clindamycin has been observed in three strains of Staphylococcus aureus and data from three patients infected with these strains are presented in detail. Clindamycin resistance followed the expected pattern by appearing in a strain of Staph. aureus with dissociated resistance to erythromycin after treatment with erythromycin and clindamycin. Low-level resistance to fusidic acid appeared in two strains in the apparent absence of exposure to that antibiotic. Labile neomycin resistance was encountered in a previously sensitive strain after topical neomycin therapy. Gentamicin resistance appeared in all three strains after topical therapy. In all three strains, a labile resistance (presumably plasmid-mediated) occurred with minimum inhibitory concentrations (MICs) of 64-128 microgram/ml but in one strain a stable resistance with MIC over 3000 microgram/ml appeared.
在三株金黄色葡萄球菌中，已观察到对新霉素、庆大霉素、夫西地酸或克林霉素产生耐药性的情况，本文详细介绍了三名感染这些菌株患者的数据。克林霉素耐药性呈现出预期模式，即在用红霉素和克林霉素治疗后，一株对红霉素具有解离耐药性的金黄色葡萄球菌出现了克林霉素耐药性。在明显未接触该抗生素的情况下，两株菌出现了对夫西地酸的低水平耐药性。在局部应用新霉素治疗后，一株先前敏感的菌株出现了不稳定的新霉素耐药性。局部治疗后，所有三株菌均出现了庆大霉素耐药性。在所有三株菌中，均出现了不稳定耐药性（可能由质粒介导），最低抑菌浓度（MIC）为64 - 128微克/毫升，但在一株菌中出现了稳定耐药性，MIC超过3000微克/毫升。
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