金黄色葡萄球菌中质粒介导的庆大霉素耐药性。
Plasmid-mediated resistance to gentamicin in Staphylococcus aureus.
作者信息
Wood D O, Carter M J, Best G K
出版信息
Antimicrob Agents Chemother. 1977 Oct;12(4):513-7. doi: 10.1128/AAC.12.4.513.
Abstract
Two strains isolated from a recent outbreak of infections by gentamicin-resistant Staphylococcus aureus were examined to determine whether genetic control of this resistance is plasmid or chromosomally mediated. Curing techniques indicated a plasmid location in both strains. Physical isolation and characterization of the plasmid deoxyribonucleic acid from one strain revealed that the determinant for gentamicin resistance resides on a 50S plasmid.
摘要
对从近期一起耐庆大霉素金黄色葡萄球菌感染暴发中分离出的两株菌株进行了检测，以确定这种耐药性的遗传控制是由质粒介导还是由染色体介导。消除技术表明这两株菌株中的耐药性均由质粒介导。对其中一株菌株的质粒脱氧核糖核酸进行物理分离和特性鉴定，结果显示庆大霉素耐药性决定簇位于一个50S质粒上。
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