OXA-14，铜绿假单胞菌中OXA-10（PSE-2）β-内酰胺酶的另一种超广谱变体。
OXA-14, another extended-spectrum variant of OXA-10 (PSE-2) beta-lactamase from Pseudomonas aeruginosa.
作者信息
Danel F, Hall L M, Gur D, Livermore D M
机构信息
Department of Medical Microbiology, London Hospital Medical College, United Kingdom.
出版信息
Antimicrob Agents Chemother. 1995 Aug;39(8):1881-4. doi: 10.1128/AAC.39.8.1881.
Abstract
Pseudomonas aeruginosa 455, isolated in Ankara, Turkey, produced a pI 6.2 beta-lactamase determined by plasmid pMLH53 and resisted all beta-lactams except carbapenems. This beta-lactamase, named OXA-14, corresponded to OXA-10 (PSE-2) except that aspartate replaced glycine at position 157 and thus is intermediate between OXA-10 and OXA-11, which has aspartate at position 157 and a further substitution at position 143.
摘要
从土耳其安卡拉分离出的铜绿假单胞菌455产生了一种由质粒pMLH53决定的pI 6.2β-内酰胺酶，该酶对除碳青霉烯类以外的所有β-内酰胺类药物均有抗性。这种β-内酰胺酶名为OXA-14，与OXA-10（PSE-2）相似，只是在第157位氨基酸处天冬氨酸取代了甘氨酸，因此介于OXA-10和OXA-11之间，OXA-11在第157位氨基酸处为天冬氨酸，且在第143位氨基酸处还有进一步的取代。
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