Ness G C, Lopez D
Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa 33612, USA.
Arch Biochem Biophys. 1995 Nov 10;323(2):404-8. doi: 10.1006/abbi.1995.0061.
Utilizing hypophysectomized and thyroidectomized rats, it is demonstrated that the rapid increase in expression of hepatic low-density lipoprotein (LDL) receptor and cholesterol 7 alpha-hydroxylase in response to thyroid hormone is due to increases in the rates of transcription of these genes. An increase in transcription of the hepatic LDL receptor gene was seen within 30 min after administration of triiodothyronine. The increase in transcription fully accounted for the increase in hepatic LDL receptor protein. Stimulation of transcription of these two genes provides for enhanced removal of LDL from serum and elimination from the body.
利用垂体切除和甲状腺切除的大鼠，已证明肝脏低密度脂蛋白（LDL）受体和胆固醇7α-羟化酶对甲状腺激素反应的表达快速增加是由于这些基因转录速率的增加。给予三碘甲状腺原氨酸后30分钟内可见肝脏LDL受体基因转录增加。转录的增加完全解释了肝脏LDL受体蛋白的增加。这两个基因转录的刺激有助于增强从血清中清除LDL并从体内消除。
