Takada A, Kida H
Department of Veterinary Hygiene and Microbiology, School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Arch Virol. 1995;140(9):1629-35. doi: 10.1007/BF01322536.
Intranasal vaccination of mice with glycoprotein B (gB) of pseudorabies virus (PRV) induced specific IgA and IgG antibody responses in the secretion of the respiratory tract, resulting in protection of the animals against intranasal challenge with a lethal dose of virulent PRV. The immune response was enhanced by the use of cholera toxin B subunit as an adjuvant. The present results indicate that local vaccination with gB is a promising strategy to confer protective immunity on animals against PRV infection by inducing secretory antibodies on their mucosal surfaces where the primary replication of the virus occurs.
用伪狂犬病病毒（PRV）的糖蛋白B（gB）对小鼠进行鼻内接种，可在呼吸道分泌物中诱导特异性IgA和IgG抗体反应，从而保护动物免受致死剂量强毒PRV的鼻内攻击。使用霍乱毒素B亚单位作为佐剂可增强免疫反应。目前的结果表明，通过在病毒主要复制的粘膜表面诱导分泌性抗体，用gB进行局部接种是一种有前景的策略，可赋予动物针对PRV感染的保护性免疫。
