Tsuchida T, Iinuma H, Nishida C, Kinoshita N, Sawa T, Hamada M, Takeuchi T
Institute of Microbial Chemistry, Tokyo, Japan.
J Antibiot (Tokyo). 1995 Oct;48(10):1104-9. doi: 10.7164/antibiotics.48.1104.
The novel antimicrobial antibiotic against Pasteurella piscicida, tetrodecamycin (1) and weakly active dihydrotetrodecamycin (2) were isolated from the fermentation broth of Streptomyces nashvillensis MJ885-mF8. They were purified by adsorption on Diaion HP-20, silica gel column chromatography and crystallization. The MICs of 1 were 6.25 approximately 12.5 micrograms/liter and 1.56 approximately 6.25 micrograms/ml against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and 12 strains of P. piscicida, respectively.
从纳什维尔链霉菌MJ885-mF8的发酵液中分离出了新型抗杀鲑气单胞菌抗生素十四元霉素（1）和弱活性二氢十四元霉素（2）。它们通过在Diaion HP-20上吸附、硅胶柱色谱法和结晶进行纯化。化合物1对包括耐甲氧西林金黄色葡萄球菌（MRSA）在内的革兰氏阳性菌和12株杀鲑气单胞菌的最低抑菌浓度分别约为6.25至12.5微克/升和1.56至6.25微克/毫升。
