Wardle J
Health Behaviour Unit, Institute of Psychiatry, University of London, UK.
J Psychosom Res. 1995 Jul;39(5):549-62. doi: 10.1016/0022-3999(94)00169-3.
The debate about possible adverse effects associated with low or lowered serum cholesterol has raised important scientific questions concerning the links between lipids and behaviour. One of the most unexpected findings has been an association between cholesterol-lowering treatment and accidental death. A similar association has also emerged among the prospective cohort studies, with higher-than-expected numbers of suicide deaths in the lowest cholesterol groups. These observations have prompted speculation that behavioural or emotional disturbances could be part of the process linking lipids and accidental death. In this paper, the epidemiological literature is reviewed briefly, then the evidence for depression as a mediating condition is discussed. Two conclusions are drawn from this review of the literature. One is that understanding the relationship between the biology of lipids and the psychobiology of mood is demonstrably an important scientific and public health issue. The second is that the introduction of new treatments or preventive programmes should include a careful evaluation of the psychological as well as the physical effects.
关于低血清胆固醇或血清胆固醇降低可能带来的不良影响的争论，引发了有关脂质与行为之间联系的重要科学问题。最出人意料的发现之一是降胆固醇治疗与意外死亡之间的关联。在前瞻性队列研究中也出现了类似的关联，在胆固醇水平最低的组中，自杀死亡人数高于预期。这些观察结果引发了一种推测，即行为或情绪障碍可能是脂质与意外死亡之间联系过程的一部分。本文简要回顾了流行病学文献，然后讨论了抑郁症作为中介条件的证据。从对文献的回顾中得出了两个结论。一是，显然，理解脂质生物学与情绪心理生物学之间的关系是一个重要的科学和公共卫生问题。二是，新治疗方法或预防方案的引入应包括对心理和身体影响的仔细评估。
