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[与丘脑病变相关的类失语症:4例左右丘脑病变患者语言障碍与左侧半球选择性激活之间的关系]

[Quasi-aphasia associated with thalamic lesions: relation between the language disorder and elective activation of the left hemisphere in 4 cases of left and right thalamic lesions].

作者信息

Elghozi D, Strube E, Signoret J L, Cambier J, Lhermitte F

出版信息

Rev Neurol (Paris). 1978 Oct;134(10):557-73.

PMID:749118
Abstract

The authors report on four patients with vascular lesions of the thalamus, three on the left side and one on the right, two of which were due to haemorrhage and two to infarcts. Language difficulties were observed in those cases with left thalamic lesions only. Speech was either slower or faster than normal, and there were verbal perseveration, semantic paraphasia, and more especially, reduction in verbal fluency with loss of control of logic, causing a true jargon in some tests in certain cases. Articulation, and phonemic programming were unaffected, as were comprehension, reading and writing. A comparison is made between these findings and those reported in the literature. Among the hypo-theses suggested, the authors subscribe to that which accepts the predominant role played by the interruption of the activating system of the left hemisphere by the thalamic lesion. The relative inactivation resulting from this could produce modifications in language dynamics and disturbances in attention in relation to language. The semantic paraphasia could be related to the intrusion of the right hemisphere apparatus into language, because of the lack of balance between the activation of each of the two hemispheres. The fact that thalamic lesions are characterized by language disorders would tend to show that sub-cortical dynamic factors constantly regulate the activation of the hemispheres.

摘要

作者报告了4例丘脑血管病变患者,其中3例在左侧,1例在右侧,2例因出血,2例因梗死。仅在左侧丘脑病变的病例中观察到语言障碍。言语速度要么比正常慢,要么比正常快,存在言语持续现象、语义性错语,更特别的是,言语流畅性降低,逻辑控制丧失,在某些测试中某些病例出现了真正的胡言乱语。发音和音素编排未受影响,理解、阅读和写作也未受影响。将这些发现与文献中报道的发现进行了比较。在所提出的假说中,作者认同那种认为丘脑病变导致左半球激活系统中断起主要作用的假说。由此导致的相对失活可能会引起语言动态变化以及与语言相关的注意力障碍。语义性错语可能与右半球机制侵入语言有关,这是因为两个半球的激活缺乏平衡。丘脑病变以语言障碍为特征这一事实倾向于表明,皮质下动态因素不断调节着半球的激活。

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