Kako M, Miura T, Usami M, Kato A, Kadowaki S
Suzuka University of Medical Science and Technology, Mie, Japan.
Biol Pharm Bull. 1995 May;18(5):785-7. doi: 10.1248/bpb.18.785.
The hypoglycemic effect of the rhizomes of Ophiopogonis Tuber (Liliaceae) was investigated in normal and streptozotocin-induced diabetic mice. The n-butanol extract of rhizomes of Ophiopogonis Tuber (BM) (100 mg/kg) reduced the blood glucose of normal mice from 201 +/- 13 to 151 +/- 7 mg/100 ml 4h after intraperitoneal administration (p < 0.054), and also significantly lowered the blood glucose of streptozotocin-induced diabetic mice from 590 +/- 28 to 470 +/- 37 mg/100 ml under similar conditions (p < 0.05). BM also tended to suppress epinephrine-induced hyperglycemia in mice. We concluded that the hypoglycemic effect of BM does not alter the insulin concentration.
研究了麦冬（百合科）根茎的降血糖作用，实验对象为正常小鼠和链脲佐菌素诱导的糖尿病小鼠。麦冬根茎正丁醇提取物（BM）（100毫克/千克）腹腔注射4小时后，可使正常小鼠血糖从201±13毫克/100毫升降至151±7毫克/100毫升（p<0.054），在类似条件下，也可使链脲佐菌素诱导的糖尿病小鼠血糖从590±28毫克/100毫升显著降至470±37毫克/100毫升（p<0.05）。BM还倾向于抑制小鼠肾上腺素诱导的高血糖。我们得出结论，BM的降血糖作用不会改变胰岛素浓度。
