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Characterization of chromosomal DNA profiles from Helicobacter pylori strains isolated from sequential gastric biopsy specimens.从连续胃活检标本中分离出的幽门螺杆菌菌株的染色体DNA图谱特征分析。
J Clin Microbiol. 1995 Sep;33(9):2496-7. doi: 10.1128/jcm.33.9.2496-2497.1995.
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本文引用的文献

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Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer.与细胞毒性和十二指肠溃疡相关的幽门螺杆菌128-kDa免疫显性抗原的分子特征
Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5791-5. doi: 10.1073/pnas.90.12.5791.
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Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production.幽门螺杆菌一种高分子量主要抗原的克隆与表达：与细胞毒素产生相关的证据
Infect Immun. 1993 May;61(5):1799-809. doi: 10.1128/iai.61.5.1799-1809.1993.
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Genome conservation in Helicobacter mustelae as determined by pulsed-field gel electrophoresis.通过脉冲场凝胶电泳确定的鼬螺杆菌基因组保守性。
FEMS Microbiol Lett. 1994 May 1;118(1-2):31-6. doi: 10.1111/j.1574-6968.1994.tb06799.x.
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The histological diagnosis of chronic gastritis in fibreoptic gastroscope biopsy specimens.纤维胃镜活检标本中慢性胃炎的组织学诊断
J Clin Pathol. 1972 Jan;25(1):1-11. doi: 10.1136/jcp.25.1.1.
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Helicobacter pylori urease activity is toxic to human gastric epithelial cells.幽门螺杆菌脲酶活性对人胃上皮细胞有毒性。
Infect Immun. 1990 Jun;58(6):1992-4. doi: 10.1128/iai.58.6.1992-1994.1990.
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Helicobacter pylori infection and the risk of gastric carcinoma.幽门螺杆菌感染与胃癌风险
N Engl J Med. 1991 Oct 17;325(16):1127-31. doi: 10.1056/NEJM199110173251603.
7
Identification, characterization, and spatial localization of two flagellin species in Helicobacter pylori flagella.幽门螺杆菌鞭毛中两种鞭毛蛋白的鉴定、特性分析及空间定位
J Bacteriol. 1991 Feb;173(3):937-46. doi: 10.1128/jb.173.3.937-946.1991.
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DNA polymorphisms in new isolates of 'Deinococcus radiopugnans'.“顽强嗜辐射球菌”新分离株中的DNA多态性
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Purification and characterization of the vacuolating toxin from Helicobacter pylori.幽门螺杆菌空泡毒素的纯化与特性分析
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Helicobacter pylori and gastroduodenal disease.幽门螺杆菌与胃十二指肠疾病
Annu Rev Med. 1992;43:135-45. doi: 10.1146/annurev.me.43.020192.001031.

从连续胃活检标本中分离出的幽门螺杆菌菌株的染色体DNA图谱特征分析。

Characterization of chromosomal DNA profiles from Helicobacter pylori strains isolated from sequential gastric biopsy specimens.

作者信息

Salama S M, Jiang Q, Chang N, Sherbaniuk R W, Taylor D E

机构信息

Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada.

出版信息

J Clin Microbiol. 1995 Sep;33(9):2496-7. doi: 10.1128/jcm.33.9.2496-2497.1995.

DOI:10.1128/jcm.33.9.2496-2497.1995
PMID:7494058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC228454/
Abstract

The restriction endonuclease profiles of DNAs from Helicobacter pylori strains isolated from 20 patients in two or more consecutive biopsy specimens over a period of up to 2 years were analyzed by pulsed-field gel electrophoresis with NotI and NruI. H. pylori strains possess a high degree of genomic diversity which was not observed to occur in vivo, and attempts to observe it in vitro were not successful.

摘要

采用NotI和NruI脉冲场凝胶电泳分析了从20例患者在长达2年的时间内获取的两份或更多份连续活检标本中分离出的幽门螺杆菌菌株DNA的限制性内切酶图谱。幽门螺杆菌菌株具有高度的基因组多样性，这种多样性在体内未被观察到，且在体外观察其多样性的尝试也未成功。