爱泼斯坦-巴尔病毒核抗原前导蛋白与热休克蛋白72/热休克蛋白73相关联。
The Epstein-Barr virus nuclear antigen leader protein associates with hsp72/hsc73.
作者信息
Mannick J B, Tong X, Hemnes A, Kieff E
机构信息
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA.
出版信息
J Virol. 1995 Dec;69(12):8169-72. doi: 10.1128/JVI.69.12.8169-8172.1995.
Abstract
Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) is important for primary B-lymphocyte growth transformation. We now demonstrate that the W repeat-encoded domain of EBNA-LP significantly associates with proteins of the heat shock protein 70 family (hsp72/hsc73). hsp72/hsc73 may mediate the previously observed interaction between EBNA-LP and the retinoblastoma protein or p53.
摘要
爱泼斯坦-巴尔病毒核抗原前导蛋白（EBNA-LP）对原发性B淋巴细胞的生长转化很重要。我们现在证明，EBNA-LP的W重复编码结构域与热休克蛋白70家族（hsp72/hsc73）的蛋白质显著相关。hsp72/hsc73可能介导了先前观察到的EBNA-LP与视网膜母细胞瘤蛋白或p53之间的相互作用。
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本文引用的文献
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